Opened in 1965, California State University, San Bernardino is a preeminent center of intellectual and cultural activity in Inland Southern California. The university serves more than 20,000 students each year and graduates about 4,000 students annually. It offers more than 70 traditional baccalaureate and master's degree programs, education credential and certificate programs, and a doctoral program.

The university also offers a range of sports, and fitness and wellness opportunities to students to enhance physical fitness, learn new skills and engage in friendly sports competition. Its office of Student Engagement supports an inclusive student life environment by offering social and co-curricular opportunities that foster student involvement and build affinity to California State University, San Bernardino. Activities available to students include wall climbing, sports clubs, Intramurals, outdoor adventures, art and music festival, and theatre and performing arts.

Cal State San Bernardino is listed among the best colleges and universities in the western United States, according to The Princeton Review, Forbes and U.S. News and World Report, in their respective annual rankings. It is part of the California State University system, the largest system of higher education in the country.