我们的研究探索了神经退行性疾病和神经发育障碍的细胞和分子基础，包括阿尔茨海默氏病，帕金森氏病，亨廷顿氏病，巴滕病，运动神经元病，精神分裂症，抑郁症和自闭症谱系障碍。在本简报中，我们着重于使用干细胞和专利特异诱导的多能干细胞，并将它们用作模型，阐明负责神经元和星形胶质细胞形成和维持的转录，表观遗传和信号调节机制，以及作为恢复失去的功能的移植工具。神经变性和中风。我们使用飞行和啮齿动物模型研究学习和记忆的分子基础。<br> <br>该部门的任务是改变神经系统疾病和精神疾病患者的治疗选择，并激发下一代神经科学家
The Basic and Clinical Neuroscience department's mission is to change the therapeutic options for people with neurological and psychiatric disorders and inspire the next generation of neuroscientists. Our vision is to link up fundamental biological research and clinical research to gain a better understanding of disease mechanisms, identify novel opportunities for intervention and test out new therapies. This will only be achieved through close collaboration of scientists and clinicians working on a common problem.<br><br>Our research explores the cellular and molecular basis of neurodegenerative and neurodevelopmental disorders including Alzheimer's disease, Parkinson's disease, Huntington's disease, motor neuron disease, schizophrenia, depression and autism spectrum disorder. We use human brain tissue, rodent and fly models, cells and patient-derived induced pluripotent stem cells to identify genes, proteins and signalling pathways implicated in the development of motor neuron disease, Alzheimer's disease and related dementias, with a view to developing novel disease-modifying therapies for the treatment of these diseases.