In the structural biology theme, we combine Cryo electron microscopy with X-ray crystallography and NMR to explore the structure of macromolecules at the highest level of atomic detail.<br><br>The dynamic behaviour of proteins in solution and how they assemble into their complex folds is explored, with particular emphasis on protein mis-folding in disease states such as Alzheimer's, on toxins from pathogenic bacteria and on photosynthetic structures.<br><br>Cryo electron tomography is used to visualise biological assemblies and processes directly in vivo. Such large datasets require expertise in computational biology to analyse and interpret results.