拉夫堡大学在研究强度（REF2014）方面是英格兰排名前十的大学，并且有资格提交给REF的拉夫堡学术人员中有66％的杰出工作被评为“世界领先”。或“国际一流”，而全国平均水平为43％。<br>在选择拉夫堡进行研究时，您将与该领域的领导者一起工作。您将受益于我们的全面支持和指导，包括量身定制的职业建议，以帮助您在研究和未来职业中取得成功。<br>项目详细信息：<br>我们的研究小组专注于杂环的合成，尤其是使用单线态氧以及烯酰胺和烯丙酰胺的活化。该化学方法可用于快速构建具有生物活性的天然产物以及具有药学相关性
More than 70 lamellarins and related pyrrole-derived alkaloids have been isolated and identified [1]. While they posses a variety of unique structural features they also exhibit fascinating and significant biological properties. These include cytotoxicity and antitumor activity, multidrug resistance (MDR), HIV-1 integrase inhibition, antibiotic activity, cell division inhibition, immuno-modulatory activity, antioxidant activity, and feeding deterrence.[ref] Traditional syntheses of this natural product class compounds have centered on palladium coupling of pyrrole bromides with aryl boronic acids with subsequent alkylation of the pyrrole nitrogen or Diels-Alder reaction of a disubstituted alkynes with subsequent functional group manipulation. Our approach will utilize our recently reported photoredox mediated addition of radicals to enamides,[2] followed by subsequent nucleophile trapping. This project will develop an intramolecular variant of this unique process that will ultimately deliver a total synthesis of the core heterocyclic structure of the lamellarins. This project will significantly increase the synthetic efficiency compared to current strategies, as well as providing an excellent training platform to the prospective PhD candidate in our new state-of-the-art laboratories here at Loughborough.