Marine sponges are a source of complex peroxide-derived polyketides natural products with unique and captivating molecular structures.1 Significantly, these natural products frequently display outstanding biological activities (antimicrobial, antiviral and anticancer) underlining their substantial therapeutic potential in addressing some of the world most pressing health concerns such as antimicrobial resistance, and the emergence of ‘world altering' viral pathogens. Manzamenone K and untenolide A2 are two unique peroxide-derived polyketides natural products that are structurally related are thereby have a common biomimetic origin. The goal of the research programme is to complete the synthesis of both manzamenone K and untenolide A. The construction of manzamenone K will be accomplished through an ambitious biomimetically inspired3 synthetic strategy, this will then provide enough material to complete the synthesis of untenolide A. With ample synthetic material of each natural product, the antimicrobial and antiviral activities will be established. It is expected that the synthesis of manzamenone K and untenolide A will represent a step-change in the construction of peroxide-derived polyketides natural products. It will showcase biomimetic structural analysis and innovative tactics in chemical synthesis, as well as strategies and methodology that will have relevance to other complex of peroxide-derived polyketides natural products of structural and biological significance, as well as providing an excellent training platform to the prospective PhD candidate in our new state-of-the-art laboratories here at Loughborough.