分子遗传学系由医学大楼管理，有近100名教职员工，其实验室位于医学大楼，最佳研究所，唐纳利细胞和生物分子研究中心，菲茨杰拉德大楼，病童医院，西奈山医院，安大略省癌症研究所和玛格丽特公主医院。分子遗传学的理学硕士和哲学博士课程为从细菌，病毒到人类的广泛遗传系统提供研究培训。研究项目包括DNA修复，重组和分离，转录，RNA剪接和催化，基因表达调控，信号转导，宿主细胞与细菌和病毒的相互作用，简单生物（蠕虫和果蝇）以及复杂生物的发育遗传学（小鼠），分子神经生物学，分子免疫学，癌症生物学和病毒学，结构生物学以及人类
The Department of Molecular Genetics is administered from the Medical Sciences Building and has nearly 100 faculty members whose labs are located within the Medical Science Building, the Best Institute, the Donnelly Centre for Cellular and Biomolecular Research, the FitzGerald Building, the Hospital for Sick Children, Mount Sinai Hospital, the Ontario Institute for Cancer Research, and Princess Margaret Hospital.<br>The Master of Science and Doctor of Philosophy programs in Molecular Genetics offer research training in a broad range of genetic systems from bacteria and viruses to humans. Research projects include DNA repair, recombination and segregation, transcription, RNA splicing and catalysis, regulation of gene expression, signal transduction, interactions of host cells with bacteria and viruses, developmental genetics of simple organisms (worms and fruit flies) as well as complex organisms (mice), molecular neurobiology, molecular immunology, cancer biology and virology, structural biology, and human genetics and gene therapy.<br>MoGen researchers studying Genetic Models of Development and Disease aim to understand how the instructions required to produce a complex multicellular organism are encoded in the genome, interpreted during embryonic development, and how errors in their implementation underlie diverse implementations pathologies, including many types of cancer. How a single cell, the fertilized egg, develops into an individual that may comprise trillions of cells has fascinated observers since its discovery. Over the past 40 years, phenomenal advances with genetic analysis and molecular biology have revealed many of the mechanisms that lay out plans of the developing body, specify the identities of different cell types, and pattern tissues and organs throughout the body. One of the striking lessons to emerge from such studies is that a small number of well-conserved regulatory pathways repeatedly act during development, in different contexts, and in organisms ranging from simple invertebrates to humans, to control decisions about cell fate, tissue growth, pattern formation, and morphogenesis. Consequently, discoveries about the workings of these pathways in simple, highly tractable organisms can readily be applied to investigate the development and genetic disease in more complex ones, including humans.