个性化的基因组学需要对个体的基因组进行测序和分析。杜克大学的教职员工是个性化基因组学领域的领导者，其目标是将基因组学知识整合到针对个别患者的基因组成量身定制的医疗保健中。杜克大学的教职员工创建了个性化和精密医学中心，并编写了有关基因组学和个性化医学领域的综合教科书。杜克大学的教师还参加了个性化基因组学运动，支持建立遗传变异数据库或对自己的基因组进行测序并向公众开放的努力。
Personalized genomics entails sequencing and analyzing the genome of an individual. Duke faculty members are leaders in the field of personalized genomics, which aims to integrate genomic knowledge in the delivery of healthcare that is tailored to an individual patient's genetic makeup. Duke faculty created the Center for Personalized and Precision Medicine and compiled a comprehensive textbook in the field, Genomics and Personalized Medicine. Duke faculty also participate in the personalized genomics movement, supporting efforts to create databases of genetic variants or having their own genome sequenced and made publicly available.