The cancer biology area of research emphasis is oriented towards modern molecular and cellular biology, molecular genetics, cellular biochemistry, and immunology especially in those areas dealing with mechanisms controlling neoplastic transformation, cellular division, differentiation, apoptosis, invasion, and metastasis. Current research of more than fifty participating faculty members in cancer biology is very diverse and includes investigations in the fields of cancer immunology, DNA replication, transcription, chromatin remodeling, molecular genetics, signal transduction, chemical carcinogenesis and the regulation of oncogenes and tumor suppressor genes. The abilities of cancer biologists to elucidate basic mechanisms of cellular transformation and molecular events in tumor progression are being applied toward improving diagnosis and treatment of cancer. In addition, cancer biologists in our program are contributing toward the understanding of basic mechanisms of growth control and cellular differentiation that can be universally applied to other disciplines, such as developmental biology, virology, immunology, and genetics. Our graduate faculty members come from diverse disciplines and conduct basic, translational and clinical research.