Researchers in the IBMS Genomics and Proteomics cluster study the information content of cells: their genomes and the sets of proteins they code for. Ongoing genomic studies range from investigations of genome structure and architecture to comparative genomics of pathogens and model organisms. In proteomics, ongoing studies include comparative analyses of the proteomes of normal and diseased tissues, studies of proteomic changes as a function of cellular differentiation and tissue microenvironment, and development of next-generation proteomic methods. Significant resources exist for high throughput, high volume DNA and protein sequencing and detailed analyses of complex, information-rich biochemical and biological samples. Students in the cluster learn how to identify and quantify changes in gene expression, from the single microRNA level up to global alterations in a proteome.