Research opportunities in the laboratories of the Integrated Program in Biochemistry (IPiB) range across many areas of biochemistry and at its intersections with other disciplines, from microbiology and cellular and developmental biology to chemistry, engineering and more. Inside the cell, proteins and nucleic acids never exist in isolation. Complexes between biomolecules are essential for a variety of cellular functions. In some cases, complexes are formed transiently as in the case of chaperones that help proteins fold or proteins that target biomolecules for degradation. In other cases, these complexes are exquisitely specific and form tight interactions that can last for days. IPiB faculty approach the problems of how biomolecules fold and interact with one another using a variety of approaches including genetics, structural biology, biophysics, and chemical probing.