We develop and apply chemical tools to understand biological problems and to propose biomedical solution. We develop and apply chemical tools to understand biological problems and to propose biomedical solution. Our key research areas include: Chemical biology approaches to cancer and other diseases, Total synthesis of biologically relevant target molecules, Natural product discovery, biosynthesis and enzymology, Structure-based drug design, Computational approaches to drug discovery and analysis, Formulation and delivery of drugs, Nanotechnology as applied to medicine, Development of new catalysts for the synthesis of active small molecules, Metals in medicine and biology, Enzymological synthesis and analysis of peptides and carbohydrates