The Immunology Research Area is a unique joint effort between several departments at UC San Diego and LJI: the Department of Medicine, Pathology , Biological Sciences, and the La Jolla Institute for Immunology. The overall goal of this research area is to provide students with exceptional and rigorous training in molecular and cellular immunology. The study of the immune system uses molecular, genetic, biochemical, and developmental approaches to understand the biomedically important issues of immunity, autoimmunity, allergy, immunodeficiency, transplantation, and cancer. Moreover, studies focusing on human disease pathogenesis often lead to insight into the fundamental mechanisms by which the immune response is regulated. Many faculty research programs now bridge the disciplines of Microbiology and Immunology to probe the specific interactions between microbial virulence factors and host innate and adaptive immune defenses. In this fashion, we gain a better understanding of the fundamental pathogenesis of infectious diseases and further development of vaccines and other immunotherapies.<br><br>Immunology faculty associated with the research area study a diverse range of topics, from fundamental mechanisms of B and T lymphocyte development and differentiation, basic mechanisms of innate immune defense involving dendritic cells, macrophages, and neutrophils, immunity against microbial pathogens as well as tumors, mucosal immunity, autoimmune disease, including diabetes, rheumatoid arthritis, and the inflammatory bowel disease, and hematopoietic stem cell and organ transplantation. A guiding principle throughout their research is the use of cutting-edge technology and multi-disciplinary approaches to fundamentally address major human health issues.