The Toxicology Program provides course work and research training to prepare prospective toxicologists and environmental health scientists for careers in academia, government, and industry. Research in the program spans an array of topics ranging from the molecular to population level consequences of toxicant exposure. Areas of research excellence within the program include elucidating relationships among cell signaling processes and stressor-induced disease and toxicity, establishing mechanisms of system-specific toxicity, using physiological and genomic approaches to understand differences in species and individual susceptibility to environmental contaminants, and unraveling gene-environment interactions. Some specific research areas include: apoptosis, endocrine disruption, trace metal bioaccumulation and detoxification, oxidative stress/gene regulation/cell toxicity, asthma and lung fibrosis, cancer and mutagenesis, ecotoxicology, developmental abnormalities, chemical exposure assessment and environmental epidemiology. Some examples of the types of environmental agents that are being investigated include chemical carcinogens, trace metals, pesticides, particulates metals, endocrine disruptors, nanoparticles and UVB radiation.