All applicants must furnish three letters of recommendation from individuals who are familiar with their scholastic or professional records.
Applicants generally will be expected to have a professional degree in one of the medical sciences (e.g., MD, DDS, DVM or equivalent) from an accredited institution or a master's degree in one of the biomedical sciences and a Graduate Record Examination (GRE) score of at least 300 for the quantitative and verbal sections.
An individual having only a baccalaureate degree but with a strong background in the physical and biological sciences may be admitted upon presenting evidence of exemplary performance on the GRE.
Exceptional veterinary students at the University of Tennessee, Knoxville, may be admitted to the accelerated dual DVM-PhD program or may continue to be enrolled officially as veterinary students only and register for CEM courses. For the latter, such students may take advantage of registering for graduate courses to be counted as elective courses in the veterinary program.

For admission to a graduate program, an international student must have an equivalent 4-year bachelor's degree with at least a 3.00 on a 4.00 scale on all previous coursework or a 3.30 on a 4.00 scale on all previous graduate work. Grading systems other than the 4.00 scale are evaluated, upon receipt of transcripts, in accordance with standard practice. Programs may require a higher average GPA for admission. Applicants with work experience or who are entering graduate study after a number of years away from an educational institution, usually five years, will be given consideration with greater flexibility relative to GPA.

Minimum score requirements for admission to the Graduate School are:
a total score of 80 on the internet-based TOEFL (iBT),
a total score of 550 or equivalent on the paper-based TOEFL (PBT), or
a 6.5 overall band score on the IELTS.