Research in Drug Discovery at the University of Wisconsin focuses on areas related to medicinal chemistry, such as small molecule development, natural products isolation and characterization, organic synthesis, and rational drug design. In collaboration with the Pharmaceutical Sciences Drug Action and Drug Delivery Cores, these new chemical entities can be subsequently evaluated via high throughput screening toward lead generation or specifically utilized to probe novel biological phenomenon toward in-depth mechanistic studies. Thus, the UWMadison Pharmaceutical Sciences Drug Discovery Core presents our graduate students and post-doctoral trainees with intensive training in modern organic chemistry coupled with a distinctive exposure to the modern applications of small molecules within biology and medicine.