我们的精神病学部门是国际公认的世界一流的临床研究和教学中心。我们专注于主要精神疾病（包括自闭症，躁郁症，抑郁症，痴呆症和精神分裂症）发展的潜在机制。我们也非常关注精神病的功能遗传学，并研究了基因变化（如DISC-1）对脑结构和功能的影响，以及它们在干细胞模型发育过程中的编程作用。我们首次证明，在精神病发作之前，结构和功能的MRI改变可以用作诊断辅助。我们还证明，在智商相匹配的人中，影像学可用于将自闭症与学习障碍区分开。我们在发现与精神病相关的基因（包括DISC-1）方面取得了实质性进展，并且在了解遗传变异
The Division of Psychiatry is internationally recognised for its research and teaching. We focus on the mechanisms underlying the development of major psychiatric disorders, including: autism and learning difficulties bipolar disorder depression and mood disorders dementia schizophrenia cognition and behaviour Research expertise We have a particular expertise in longitudinal, clinical and biological studies of clinical and population-based cohort studies of people with or at high risk of mental disorders. The studies we have recruited or have worked on include: Edinburgh High Risk Studies of young people at high genetic cognitive risk for schizophrenia bipolar disorder and other related conditions Generation Scotland - a family and population-based study of 24,000 individuals recruited from the general population of Scotland. UK Biobank - a UK- and population-based study of more than half a million people from across England, Wales and Scotland In psychiatric genetics, we take part in international genome-wide association studies of psychiatric disorders - including the Psychiatric Genomics Consortium (PGC) and ENIGMA that seeks to identify the genetic causes of psychiatric disorders. Our work then utilities the findings in order to identify the environmental risk factors and neurobiological mechanisms of mental disorders, using genetic factors as causal anchors. Research methods Our work relies on a number of genomic technologies, including: genome-wide association studies (GWAS) DNA sequencing DNA methylation and expression analysis proteomics structural and functional neuroimaging In collaboration with others, we also work on stem-cell, cultured tissue (including organoids) and in vivo models of psychiatric disorders and we are also involved in a number of clinical trials of novel interventions. Centre for Clinical Brain Sciences The Division of Psychiatry is a part of the Centre for Clinical Brain Sciences (CCBS) in the Edinburgh Medical School. CCBS integrates laboratory and clinical research to study the causes, consequences and treatment of major brain disorders. Centre for Clinical Brain Sciences