我们的研究主题包括：肿瘤干细胞在葡萄膜黑色素瘤发生和发展中的作用，鉴定转移调节剂，葡萄膜黑色素瘤转移性肝病灶的分子特征：寻找治疗靶点，犬和人葡萄膜黑色素瘤的比较数字转录谱，蛋白质组学发现转移性UM中的血清生物标志物，新型抑制性VEGF异构体在眼黑色素瘤，结膜黑色素瘤中的作用：一项将基线特征与组织学和遗传学相关联的多中心研究。我们的设施使我们能够将生物医学研究从患者样本带到实验室，反之亦然，从新生成的药物化合物进入临床试验。
The University has invested over 20 million in cancer research which has been used for the creation of several new posts in the Department, and in the establishment of the University of Liverpool Cancer Research Centre (ULCRC) building. Professor Sarah Coupland is a Lead of the Liverpool Ocular Oncology Research Group (LOORG), Professor Sarah Coupland is a Consultant Histopathologist and the George Holt Chair of Pathology, University of Liverpool. She is also the Director of the North West Cancer Research Centre-University of Liverpool. The group focuses clinical on molecular genetics of cancers with particular interests in uveal melanoma, conjunctival melanoma, intraocular and ocular adnexal lymphomas. ITEM: CR-UK funded multicentre single arm phase II study of imatinib in good performance status patients with c-kit positive metastatic uveal melanoma. Associated biosamples collected for translational purposes include, blood samples, formalin fixed paraffin embedded tissue blocks of the metastatic lesions and matched primary tumours (where available).<br><br>SUAVE: CR-UK funded multicentre randomised phase II study of sunitinib in good performance status patients with metastatic uveal melanoma. Associated biosamples collected for translational purposes include, blood samples, formalin fixed paraffin embedded tissue blocks of the metastatic lesions and matched primary tumours (where available).