Breast cancer is the most common form of cancer in humans, with over 50,000 women clinically diagnosed with breast cancer in the UK in 2015. Treatment of breast cancer has rapidly improved, due to early detection, and development of new anti-cancer drugs, however, the treatment of breast cancer exerts a significant deleterious effect on our cardiovascular system. This cardio-toxicity leads to an elevated risk of cardiovascular disease (CVD) in breast cancer survivors (Sharrma et al., 2019). Evidence from our laboratory suggests that physical activity status could affect how our blood vessels respond to chemotherapy treatment, with reduced rates of endothelial cell death and activation with greater physical fitness and activity. However, studies investigating the association between physical activity or inactivity on circulating risk factors and future cardiovascular risk are limited. The aim of this MRes is to investigate the association of physical activity and inactivity on cardiovascular risk factors and future CVD risk using available large cohort study datasets. You will be given the opportunity to engage in an active postgraduate research group. You will be provided with extensive training in statistical analysis using R software and epidemiological research methods. You will be given the opportunity to engage with an active postgraduate research community (including the chance to present at national/international conferences) and take part in a full training programme aimed at supporting progression to a successful research career.