Biological processes have been used for centuries to produce wine, beer and fermented foods. As processes and manufacturing efficiencies have improved, products such as antibiotics, vitamins, enzymes, specialty chemicals and even commodity chemicals have and are being produced using bioprocesses. Bioprocesses for these applications typically employ microbial fermentation processes, filtration or centrifugation, precipitation and/or crystallization and drying. Principles of microbiology, fermentation technology, reaction kinetics, separation science and process economics are typically required to develop large cost efficient manufacturing processes.