围绕该子学科的广泛研究项目包括合成，结构表征和结构确定，化学反应性研究以及有机转化和相关的反应性中间体和过渡态的机制，主要是碳的生物/生物化学活性化合物。 。这里的研究小组广泛地关注核苷和核苷样化合物，蛋白质/酶结合剂和仿生复合物的合成。还对反应和反应性中间体以及结构对反应性和机理的影响进行了系统的研究，主要是亲电子物种，例如环氧化物，重氮离子和碳正离子。其他感兴趣的领域包括核苷和多核苷酸的共价加合物的结构和影响其分布的因素。
A wide range of research projects center on this sub-discipline including synthesis, structural characterization and structure determination, the study of chemical reactivity, and the mechanisms of organic transformations and associated reactive intermediates and transition states, chiefly of biologically/biochemically active compounds of carbon. Groups here focus extensively on synthesis of nucleoside and nucleoside-like compounds, protein/enzyme binding agents and bio-mimetic complexes. There is also systematic study of reactions and reactive intermediates and the effects of structure on reactivity and mechanism, predominantly of electrophilic species such as epoxides, diazonium ions and carbocations. Additional areas of interest include the structure of, and factors affecting the distribution of, covalent adducts of nucleosides and polynucleotides.