Graduate students in organic chemistry of natural products take a one-year course sequence in mechanistic organic chemistry and another in synthetic organic chemistry. Additionally, one-semester courses are required in advanced physical chemistry and the organic chemistry of natural products. Courses in biochemistry, inorganic chemistry, statistics and specialized courses in chemistry or biology may be arranged and selected by the student in consultation with faculty. Research in the field of organic chemistry of natural products takes three paths. These paths are the isolation and characterization of new natural substances, the synthesis of new or improved syntheses of better-known natural substances, and the study of the relation of molecular structure to biological response. Chemical research in each of these areas is coupled with biological testing. Research involving isolation and synthetic chemistry requires the student to develop expertise in separation techniques, such as the several methods of chromatography and spectrometric identification of molecules. Successful investigation in structure/activity relationships requires the student to become familiar with statistical methods of analysis.