Systems biology is the coordinated study of biological systems, at the cellular, organ, or whole body level, which aims at achieving a systems-level understanding of biological processes. Systems biology lies at the interface of engineering, computer science, and molecular/cell biology and involves sophisticated computational and high-throughput experimental approaches. One of the key outcomes of systems biology is the development of biomedical models describing the system which can lead to precision medicine approaches to tailor treatments to individuals. Health care analytics makes use of similar Big Data approaches as systems biology, but the focus is on extracting knowledge about diseases and intervention strategies from extremely large data sets such as those maintained by hospitals and health care providers.