计算和理论生物工程小组致力于解释，建模和提供操纵与医学相关的生物系统的方法。研究范围从生物力学到蛋白质-蛋白质相互作用，再到干细胞分化和免疫系统疗法。感兴趣的一般领域包括骨骼和软骨力学，应力对干细胞分化的影响，糖胺聚糖的序列和结构特性，耳蜗，外毛细胞膜的纳米机电转导，分子成像标志物的表征，结构生物学，进化和免疫系统疗法，生化回路的设计原理，以及基于药物的异常蛋白相互作用抑制。
The quantitative, computational, and theoretical bioengineering group works to explain, model, and provide the means to manipulate medically-related biological systems.<br><br>Investigations range from biomechanics to protein-protein interactions, to stem cell differentiation and immune system therapies. These investigations often employ a systems biology approach to understand how biological processes, within cells, a group of cells, or an entire tissue work at the ‘network level', and generally seeks to determine how biological components (e.g., genes, proteins, and biochemical reactions) interact to produce defined physiological responses and behaviors.<br><br>Ultimately, this multi-scale understanding of biological systems is central to gaining a better understanding of the causes and progression of human diseases, and promises to lead to new therapeutic strategies that can be increasingly personalized. General areas of interest include connective tissue mechanics, environmental effects on stem cell differentiation, biofilms, sequence and structure properties of biomacromolecules, nanoelectromechanical transduction in cochlear, outer-hair cell membranes, neuroscience, characterization of molecular imaging markers, structural biology, evolution and immune system therapies, and design principles of biochemical circuits.